Surgical Treatment of Patients With Infective Endocarditis After Transcatheter Aortic Valve Implantation.
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Mangner Norman, del Val David, Abdel-Wahab Mohamed, Crusius Lisa, Durand Eric, Ihlemann Nikolaj, Urena Marina, Pellegrini Costanza, Giannini Francesco, Gasior Tomasz, Wojakowski Wojtek, Landt Martin, Auffret Vincent, Sinning Jan Malte, Cheema Asim N, Nombela-Franco Luis, Chamandi Chekrallah, Campelo-Parada Francisco, Munoz-Garcia Erika, Herrmann Howard C, Testa Luca, Kim Won-Keun, Castillo Juan Carlos, Alperi Alberto, Tchetche Didier, Bartorelli Antonio L, Kapadia Samir, Stortecky Stefan, Amat-Santos Ignacio, Wijeysundera Harindra C, Lisko John, Gutiérrez-Ibanes Enrique, Serra Vicenç, Salido Luisa, Alkhodair Abdullah, Livi Ugolino, Chakravarty Tarun, Lerakis Stamatios, Vilalta Victoria, Regueiro Ander, Romaguera Rafael, Kappert Utz, Barbanti Marco, Masson Jean-Bernard, Maes Frédéric, Fiorina Claudia, Miceli Antonio, Kodali Susheel, Ribeiro Henrique B, Mangione Jose Armando, Sandoli de Brito Fabio, Actis Dato Guglielmo Mario, Rosato Francesco, Ferreira Maria-Cristina, Correia de Lima Valter, Colafranceschi Alexandre Siciliano, Abizaid Alexandre, Marino Marcos Antonio, Esteves Vinicius, Andrea Julio, Godinho Roger R, Alfonso Fernando, Eltchaninoff Helene, Søndergaard Lars, Himbert Dominique, Husser Oliver, Latib Azeem, Le Breton Hervé, Servoz Clement, Pascual Isaac, Siddiqui Saif, Olivares Paolo, Hernandez-Antolin Rosana, Webb John G, Sponga Sandro, Makkar Raj, Kini Annapoorna S, Boukhris Marouane, Gervais Philippe, Côté Mélanie, Holzhey David, Linke Axel, Rodés-Cabau Josep
Аннотация
OBJECTIVES: The goal of this study was to investigate the clinical characteristics and outcomes of patients with TAVI-IE treated with cardiac surgery and antibiotics (IE-CS) compared with patients treated with antibiotics alone (IE-AB).
METHODS: Crude and inverse probability of treatment weighting analyses were applied for the treatment effect of cardiac surgery vs medical therapy on 1-year all-cause mortality in patients with definite TAVI-IE. The study used data from the Infectious Endocarditis after TAVI International Registry.
RESULTS: Among 584 patients, 111 patients (19%) were treated with IE-CS and 473 patients (81%) with IE-AB. Compared with IE-AB, IE-CS was not associated with a lower in-hospital mortality (HRunadj: 0.85; 95% CI: 0.58-1.25) and 1-year all-cause mortality (HRunadj: 0.88; 95% CI: 0.64-1.22) in the crude cohort. After adjusting for selection and immortal time bias, IE-CS compared with IE-AB was also not associated with lower mortality rates for in-hospital mortality (HRadj: 0.92; 95% CI: 0.80-1.05) and 1-year all-cause mortality (HRadj: 0.95; 95% CI: 0.84-1.07). Results remained similar when patients with and without TAVI prosthesis involvement were analyzed separately. Predictors for in-hospital and 1-year all-cause mortality included logistic EuroSCORE I, Staphylococcus aureus, acute renal failure, persistent bacteremia, and septic shock.
CONCLUSIONS: In this registry, the majority of patients with TAVI-IE were treated with antibiotics alone. Cardiac surgery was not associated with an improved all-cause in-hospital or 1-year mortality. The high mortality of patients with TAVI-IE was strongly linked to patients' characteristics, pathogen, and IE-related complications.