Recent developments in metal catalyzed asymmetric addition of phosphorus nucleophiles.

The metal-catalyzed asymmetric addition of phosphorus nucleophiles is one of the most efficient and reliable approaches for the construction of new carbon-phosphorus bonds. In recent years, great achievements have been made in this area, and many powerful methods have been developed for these transformations with high efficiency, low ligand loading and excellent selectivity. This tutorial review covers recent efforts in the constructions of P-C bonds through asymmetric additions of phosphorus nucleophiles including dialkyl phosphites, secondary phosphine oxides and secondary phosphines.