Pharmacological reports : PR · 2014
Involvement of PKA, PKC, CAMK-II and MEK1/2 in the acute antidepressant-like effect of creatine in mice.
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Cunha Mauricio P, Budni Josiane, Pazini Francis L, Oliveira Ágatha, Rosa Julia M, Lopes Mark W, Leal Rodrigo B, Rodrigues Ana Lúcia S
Аннотация
BACKGROUND: The aim of this study was to investigate the involvement of signaling pathways on the creatine antidepressant-like effect in the tail suspension test (TST) in mice.
METHODS: The TST was used to assess the antidepressant-like properties of creatine.
RESULTS: The anti-immobility effect of creatine (1mg/kg, p.o.) in the TST was blocked by i.c.v. pretreatment with H-89 (1μg/site, PKA inhibitor), KN-62 (1μg/site, CAMK-II inhibitor), chelerythrine (1μg/site, PKC inhibitor), U0126 (5μg/site, MEK1/2 inhibitor) or PD09058 (5μg/site, MEK1/2 inhibitor).
CONCLUSION: These results suggest that the antidepressant-like effect of creatine is dependent on PKA, CaMK-II, PKC and MEK 1/2 activation.
METHODS: The TST was used to assess the antidepressant-like properties of creatine.
RESULTS: The anti-immobility effect of creatine (1mg/kg, p.o.) in the TST was blocked by i.c.v. pretreatment with H-89 (1μg/site, PKA inhibitor), KN-62 (1μg/site, CAMK-II inhibitor), chelerythrine (1μg/site, PKC inhibitor), U0126 (5μg/site, MEK1/2 inhibitor) or PD09058 (5μg/site, MEK1/2 inhibitor).
CONCLUSION: These results suggest that the antidepressant-like effect of creatine is dependent on PKA, CaMK-II, PKC and MEK 1/2 activation.
Предметные рубрики MeSH
AnimalsAntidepressive AgentsBehavior, AnimalCalcium-Calmodulin-Dependent Protein Kinase Type 2CreatineCyclic AMP-Dependent Protein KinasesDisease Models, AnimalHindlimb SuspensionInjections, IntraventricularMaleMiceMitogen-Activated Protein Kinase KinasesMotor ActivityProtein Kinase CProtein Kinase InhibitorsProtein Serine-Threonine KinasesSignal TransductionStress, Psychological