Медицинская библиотека · Pharmacological reports : PR · 2014

Involvement of PKA, PKC, CAMK-II and MEK1/2 in the acute antidepressant-like effect of creatine in mice.

Cunha Mauricio P, Budni Josiane, Pazini Francis L, Oliveira Ágatha, Rosa Julia M, Lopes Mark W, Leal Rodrigo B, Rodrigues Ana Lúcia S

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

BACKGROUND

The aim of this study was to investigate the involvement of signaling pathways on the creatine antidepressant-like effect in the tail suspension test (TST) in mice.

METHODS

The TST was used to assess the antidepressant-like properties of creatine.

RESULTS

The anti-immobility effect of creatine (1mg/kg, p.o.) in the TST was blocked by i.c.v. pretreatment with H-89 (1μg/site, PKA inhibitor), KN-62 (1μg/site, CAMK-II inhibitor), chelerythrine (1μg/site, PKC inhibitor), U0126 (5μg/site, MEK1/2 inhibitor) or PD09058 (5μg/site, MEK1/2 inhibitor).

CONCLUSION

These results suggest that the antidepressant-like effect of creatine is dependent on PKA, CaMK-II, PKC and MEK 1/2 activation.

Для цитирования: Cunha Mauricio P, Budni Josiane, Pazini Francis L, Oliveira Ágatha, Rosa Julia M, Lopes Mark W, Leal Rodrigo B, Rodrigues Ana Lúcia S. Involvement of PKA, PKC, CAMK-II and MEK1/2 in the acute antidepressant-like effect of creatine in mice.. Pharmacological reports : PR. 2014. DOI: 10.1016/j.pharep.2014.03.004.

Предметные рубрики MeSH

Animals Antidepressive Agents Behavior, Animal Calcium-Calmodulin-Dependent Protein Kinase Type 2 Creatine Cyclic AMP-Dependent Protein Kinases Disease Models, Animal Hindlimb Suspension Injections, Intraventricular Male Mice Mitogen-Activated Protein Kinase Kinases Motor Activity Protein Kinase C Protein Kinase Inhibitors Protein Serine-Threonine Kinases Signal Transduction Stress, Psychological

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