Clinics in perinatology · 2019
Drugs for the Prevention and Treatment of Bronchopulmonary Dysplasia.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Mandell Erica W, Kratimenos Panagiotis, Abman Steven H, Steinhorn Robin H
Аннотация
Rates of bronchopulmonary dysplasia (BPD) are increasing. After preterm birth, there are important developmental periods in which neonates are more vulnerable to stressful events. These periods are opportunities for pharmacologic interventions. Many drugs remain inadequately tested and no new drugs have been approved in more than 25 years for BPD prevention or therapy. More progress is needed in defining appropriate end points based on the pathophysiology of BPD and postdischarge chronic pulmonary insufficiency of prematurity and to develop effective new drugs. In addition, much work is needed to better define perinatal factors, early postnatal findings, and physiologic phenotypes or endotypes.
Предметные рубрики MeSH
Administration, InhalationAdrenal Cortex HormonesBronchodilator AgentsBronchopulmonary DysplasiaCaffeineDiureticsFemaleHumansInfant, NewbornInfant, PrematureInsulin-Like Growth Factor IMesenchymal Stem Cell TransplantationNitric OxideOxygen Inhalation TherapyPhosphodiesterase 5 InhibitorsPhosphodiesterase InhibitorsPregnancyPrenatal CareProgesteroneProgestinsPulmonary SurfactantsSildenafil CitrateVitamin AVitamins