iScience · 2021
Host parameters and mode of infection influence outcome in SARS-CoV-2-infected hamsters.
СтатьяНазвание и аннотация: Перевод в очереди
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Griffin Bryan D, Warner Bryce M, Chan Mable, Valcourt Emelissa, Tailor Nikesh, Banadyga Logan, Leung Anders, He Shihua, Boese Amrit S, Audet Jonathan, Cao Wenguang, Moffat Estella, Garnett Lauren, Tierney Kevin, Tran Kaylie N, Albietz Alixandra, Manguiat Kathy, Soule Geoff, Bello Alexander, Vendramelli Robert, Lin Jessica, Deschambault Yvon, Zhu Wenjun, Wood Heidi, Mubareka Samira, Safronetz David, Strong James E, Embury-Hyatt Carissa, Kobasa Darwyn
Аннотация
The golden hamster model of SARS-CoV-2 infection recapitulates key characteristics of COVID-19. In this work we examined the influence of the route of exposure, sex, and age on SARS-CoV-2 pathogenesis in hamsters. We report that delivery of SARS-CoV-2 by a low- versus high-volume intranasal or intragastric route results in comparable viral titers in the lung and viral shedding. However, low-volume intranasal exposure results in milder weight loss, whereas intragastric exposure leads to a diminished capacity to regain body weight. Male hamsters, and particularly older male hamsters, display an impaired capacity to recover from illness and delayed viral clearance. These factors were found to influence the nature of the host inflammatory cytokine response but had a minimal effect on the quality and durability of the humoral immune response and susceptibility to re-infection. These data further elucidate key factors that impact pre-clinical challenge studies carried out in the hamster model of COVID-19.