Sleep · 2005
Sleep during concanavalin-A-induced hepatitis and peritonitis in inbred mice.
СтатьяПоддержка NIH: внешняя программаПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
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Toth Linda A, Hughes Larry F, Rehg Jerold E
Аннотация
STUDY OBJECTIVES: To assess the suitability of concanavalin-A-induced hepatitis as a model for investigating the relationships between hepatic disease and alterations in somnolence.
DESIGN: We characterized the sleep patterns of various strains of inbred mice undergoing ConA-induced inflammation.
SETTING: Southern Illinois University School of Medicine, Springfield, IL.
INTERVENTION: Intravenous or intraperitoneal administration of concanavalin-A.
PARTICIPANTS: Inbred mice.
MEASUREMENTS AND RESULTS: Intravenous and intraperitoneal administration of concanavalin-A both elicited strain-dependent changes in slow-wave sleep. ConA treatment also reduced spontaneous locomotor activity. ConA-induced changes in slow-wave sleep varied with dose, route of administration, and circadian period of administration. As compared with the other strains, C57BL/6J mice had lower serum concentrations of interferon-gamma at 8 hours after ConA administration.
CONCLUSIONS: These data provide the first demonstration that sleep enhancement and reduced locomotor activity accompany hepatic inflammation in mice.
DESIGN: We characterized the sleep patterns of various strains of inbred mice undergoing ConA-induced inflammation.
SETTING: Southern Illinois University School of Medicine, Springfield, IL.
INTERVENTION: Intravenous or intraperitoneal administration of concanavalin-A.
PARTICIPANTS: Inbred mice.
MEASUREMENTS AND RESULTS: Intravenous and intraperitoneal administration of concanavalin-A both elicited strain-dependent changes in slow-wave sleep. ConA treatment also reduced spontaneous locomotor activity. ConA-induced changes in slow-wave sleep varied with dose, route of administration, and circadian period of administration. As compared with the other strains, C57BL/6J mice had lower serum concentrations of interferon-gamma at 8 hours after ConA administration.
CONCLUSIONS: These data provide the first demonstration that sleep enhancement and reduced locomotor activity accompany hepatic inflammation in mice.