Annali italiani di chirurgia · 2018
Propofol: a safe anaesthetic drug in experimental cardiac surgery in rabbits.
СтатьяНазвание и аннотация: Перевод в очереди
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Giuliani Enrico, Manenti Antonio, Barbieri Alberto, Farinetti Alberto, Mattioli Anna Vittoria
Аннотация
ACKGROUND: Experimental surgery needs a pharmacological approach that can interfere with cardiac function.
CASE REPORT: In a animal model of regenerative medicine of myocardium we use an anaesthesiological protocol that included Propofol, a benzodiazepine (Midazolam) and an alpha-2 adrenergic agent.
RESULTS: In a group of 15 rabbits undergoing cardiac surgery we reported 1 arrhythmic complication during stem cell injection.
DISCUSSION: The functional cardio- respiratory depressor activity of Propofol was compensated by alpha-2 adrenergic drugs, avoiding serious complications. We hypothesize that the functional cardio-respiratory depressor of different anaesthesiological drugs can be reversed by the contemporary administration of with adrenergic agents.
KEY WORDS: Arrhythmias, Cardiac ischemia, Cardiovascular toxicity, Propofol.
CASE REPORT: In a animal model of regenerative medicine of myocardium we use an anaesthesiological protocol that included Propofol, a benzodiazepine (Midazolam) and an alpha-2 adrenergic agent.
RESULTS: In a group of 15 rabbits undergoing cardiac surgery we reported 1 arrhythmic complication during stem cell injection.
DISCUSSION: The functional cardio- respiratory depressor activity of Propofol was compensated by alpha-2 adrenergic drugs, avoiding serious complications. We hypothesize that the functional cardio-respiratory depressor of different anaesthesiological drugs can be reversed by the contemporary administration of with adrenergic agents.
KEY WORDS: Arrhythmias, Cardiac ischemia, Cardiovascular toxicity, Propofol.
Предметные рубрики MeSH
Adrenergic alpha-2 Receptor AgonistsAnesthesia, IntravenousAnesthetics, IntravenousAnimalsArrhythmias, CardiacBradycardiaCardiac Surgical ProceduresDrug InteractionsHemodynamicsHypnotics and SedativesIntraoperative ComplicationsMaleMesenchymal Stem Cell TransplantationMidazolamMyocardial Reperfusion InjuryPropofolRabbitsSpecies Specificity