Immunopharmacology and immunotoxicology · 2007
Selective effect of mercury on Th2-type cytokine production in humans.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
de Vos Gabriele, Abotaga Sherif, Liao Zenghua, Jerschow Elina, Rosenstreich David
Аннотация
UNLABELLED: Mercury induces autoimmune disease and increases IL-4 production and IgE levels in certain rodent strains. The object of this study was to determine if mercury was capable of inducing Th2 cytokine production in human leucocytes. Human peripheral blood mononuclear cells (PBMC) were incubated with PMA/ionomycin or Con A in the presence or absence of methyl mercury (CH(3)Hg) or mercuric chloride (HgCl(2)). IL-4 and gamma-IFN were measured by ELISA.
RESULTS: IL-4 production significantly increased at low concentrations of CH(3)Hg (0.5 uM, p < 0.01), while gamma-IFN production was suppressed starting at CH(3)Hg 2 uM (p = 0.004). Inorganic mercury (HgCl(2)) increased IL-4 only at concentrations 10-20 times higher than CH(3)Hg. These findings suggest a mechanism by which mercury could trigger or potentiate TH2 cytokine production in humans.
RESULTS: IL-4 production significantly increased at low concentrations of CH(3)Hg (0.5 uM, p < 0.01), while gamma-IFN production was suppressed starting at CH(3)Hg 2 uM (p = 0.004). Inorganic mercury (HgCl(2)) increased IL-4 only at concentrations 10-20 times higher than CH(3)Hg. These findings suggest a mechanism by which mercury could trigger or potentiate TH2 cytokine production in humans.