[Effect of Composite Salviae Dropping Pill on function of platelet activation in patients with unstable angina pectoris].

OBJECTIVE

To explore the effect of Composite Salviae Dropping Pill (CSDP) on the level of alpha-granule membrane protein-140 (GMP-140) in unstable angina pectoris (UAP).

METHODS

Forty-two patients of UAP were randomly divided into the CSDP group and the control group, 21 cases in each group. The two groups were all received the treatment of aspirin and other conservative agents, and CSDP was given to the CSDP group orally, 10 pills three times a day for 4 weeks additionally. The GMP-140 level was determined by ELISA, changes of symptoms of angina, ECG were observed before and after treatment. Besides, 22 healthy persons were selected as the normal control.

RESULTS

The level of GMP-140 in the two treated groups was significantly higher than that in the normal control group before treatment (P < 0.01). After 4 weeks' treatment of CSDP, the symptoms of angina, ischemia feature in ECG improved in the CSDP group more apparently than those in the control group. Moreover, the GMP-140 level in the CSDP group was reduced significantly as compared with the control group, and to approach the level of normal (P > 0.05), while in the control group, it was higher as compared with the normal control (P < 0.05).

CONCLUSION

CSDP combined with aspirin may inhibit platelet activation in UAP patients and showed good effect in ameliorating angina in clinical practice.