[Zhonghua yan ke za zhi] Chinese journal of ophthalmology · 1997
[A study of immunopathology on salivary gland of Sjögren's syndrome].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Luo F, Zhang H, Zhou Z
Аннотация
OBJECTIVE: To understand the mechanism and pathogenesis of Sjögrens syndrome (SS) and to provide theoretical basis for the treatment of SS.
METHOD: Salivary gland lymphocytes (SGL) from 20 patients with SS were analyzed by using immunohistochemical avidin-biotin-peroxidase complex (ABC) method.
RESULT: A predominance of T cells was found in SGL with the majority belonging to the CD4+(TH), and the CD8+(TS) subset was obviously decreased, while the CD4+/CD8+ ratio was considerably increased. Most lymphocytes expressed HLA-DR antigen in SS. The deficiency of Ts and the overactivity of TH would result in autoantibody production, that would contribute to the reaction of autoimmune.
CONCLUSION: The immune hyperfunction at exocrine glands of SS is the direct cause of the pathogenesis of SS. SS is further proved to be an autoimmune disease.
METHOD: Salivary gland lymphocytes (SGL) from 20 patients with SS were analyzed by using immunohistochemical avidin-biotin-peroxidase complex (ABC) method.
RESULT: A predominance of T cells was found in SGL with the majority belonging to the CD4+(TH), and the CD8+(TS) subset was obviously decreased, while the CD4+/CD8+ ratio was considerably increased. Most lymphocytes expressed HLA-DR antigen in SS. The deficiency of Ts and the overactivity of TH would result in autoantibody production, that would contribute to the reaction of autoimmune.
CONCLUSION: The immune hyperfunction at exocrine glands of SS is the direct cause of the pathogenesis of SS. SS is further proved to be an autoimmune disease.