Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2013
Immunostimulatory activity of polysaccharides from Cheonggukjang.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Lee Seung-Jun, Rim Hong-Kun, Jung Ji-Yun, An Hyo-Jin, Shin Ji-Sun, Cho Chang-Won, Rhee Young Kyoung, Hong Hee-Do, Lee Kyung-Tae
Аннотация
Cheonggukjang is a Korean whole soybean paste fermented by Bacillus subtilis and regarded as a healthy food. The objective of this study was to investigate the immunostimulatory activity of polysaccharides from Cheonggukjang (PSCJ) in RAW 264.7 macrophages and an animal model. PSCJ induced mRNA expressions of inducible nitric oxide synthase and tumor necrosis factor-α (TNF-α) by activating nuclear factor-κB, and subsequently increased the productions of nitric oxide (NO) and TNF-α in murine recombinant interferon-γ-primed RAW 264.7 macrophages. Furthermore, after daily oral administration of PSCJ, immobility time decreased significantly in the PSCJ-administered group (200 or 400 mg/kg) on day 10. Taken together, these results suggest that the PSCJ has a possible role improving immune function through regulatory effects on immunological parameters, such as NO and TNF-α productions and changes in indicators related to fatigue.
Предметные рубрики MeSH
AnimalsBacillus subtilisCell Line, TransformedCells, CulturedDietDietary CarbohydratesFatigueFermentationFunctional FoodGene Expression RegulationImmunologic FactorsMacrophage ActivationMacrophagesMaleMiceMice, Inbred ICRNitric Oxide Synthase Type IIPolysaccharidesRepublic of KoreaSoy FoodsSpleenTumor Necrosis Factor-alpha