A report of a rare immediate reaction after ingestion of acetaminophen.

BACKGROUND

Acetaminophen hypersensitivity is rare and, when seen, is usually in association with sensitivity to nonsteroidal anti-inflammatory drugs.

METHODS

This is a case report of an immediate reaction to acetaminophen, confirmed by a drug challenge, in a subject who tolerated ibuprofen.

RESULTS

After an oral challenge with 50 mg of acetaminophen, the subject had generalized pruritus, urticaria, and dyspnea.

CONCLUSIONS

This patient demonstrates a rare but potentially severe reaction to acetaminophen that may occur in patients who are not otherwise sensitive to other nonsteroidal anti-inflammatory drugs.