European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2002
Characterization of the complexes of furosemide with 2-hydroxypropyl-beta-cyclodextrin and sulfobutyl ether-7-beta-cyclodextrin.
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Spamer Elisma, Müller Douw G, Wessels Philippus L, Venter Johannes P
Аннотация
The purpose of this study was to prepare and characterize complexes of furosemide with 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) and sulfobutyl ether-7-beta-cyclodextrin (SBE-7-beta-CD). Solid complexes of furosemide with 2-HP-beta-CD and SBE-7-beta-CD were prepared by using both a freeze-drying and kneading method. Physical mixtures were prepared for comparison. The inclusion complexes were characterized by differential scanning calorimetry, X-ray diffractometry (XRD) and 1H nuclear magnetic resonance spectroscopy (1H-NMR). 1H-NMR, and especially the use of the two-dimensional ROESY spectrum, was used to determine the position of the furosemide molecule inside the cyclodextrin cavity. 1H-NMR studies showed that furosemide fit into the cyclodextrin torus cavity with its furane ring nearest to the primary hydroxyl side.