[Placebo-controlled EEG-double blind study with the further purified TBE-vaccine (author's transl)].

In a placebo-controlled double blind study at random with 72 healthy persons the effect of an active TBE-vaccination (purified TBE vaccine) on EEG was investigated. 49 out of 72 examined persons could be examined twice, before and 3 to 5 days after vaccination respectively. The EEG was registered according to the international 10-20 electrode system in bipolar, unipolar and source derivations, using a 16 channel Elema-Schoenander electroencephalograph. The registration was made at rest, with hyperventilation and photo-stimulation. The EEG was registered on a tape-recorder and, using a computer, an automatic analysis (Fourier-Analysis) of the CZ-O2 derivations was performed, in order to get more exact results and a quantification of the basic-rhythmus. The visual evaluation and automatic analysis showed no significant changes of the EEG after TBE vaccination. There results were statistically determined by T-Tests and by discriminance analysis.