Journal of ethnopharmacology · 2025
The leaves of Flabellaria paniculata Cav. (Malphigiaceae) exhibit anti-inflammatory, antioxidant and antinociceptive activities invivo.
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Sofidiya Margaret O, Olaosilo Janet, Alarape Dolapo, Owolabi Oluwatobi, Ajayi Abayomi M
Аннотация
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Flabellaria paniculata Cav. (Malpighiaceae) are used in the treatment of conditions associated with inflammation and pain.
AIM OF THE STUDY: The study aimed at evaluating the anti-inflammatory and antinociceptive effects of ethanol extract from the leaves of F. paniculata.
MATERIALS AND METHODS: The extract was obtained by maceration with ethanol (95 %) and characterized by GC-MS. The anti-inflammatory effect was assessed in carrageenan, serotonin, histamine-induced paw oedema and xylene-induced ear oedema models at the dose of 50, 100 and 200 mg/kg. Antioxidant parameters and cytokine production (IL-6, and TNF-α) levels were determined in carrageenan air pouch model. The antinociceptive property was also evaluated.
RESULTS: The extract at 200 mg/kg showed significant anti-inflammatory activity at 2 h (39.66 %, inhibition) which lasted for 5 h (70.37 %, inhibition) in carrageenan paw oedema. In the air pouch model, the extract decreased neutrophils and monocytes counts in the exudate but not lymphocytes count. At the dose of 200 mg/kg, the release of TNF-α and IL-6 was inhibited by 56.6 % and 35.9 %, respectively. The extract boosted catalase and SOD activities in addition to GSH level. Xylene-induced ear oedema was inhibited by 52.25, 62.62 and 64.97 %, at the dose of 50, 100 and 200 mg/kg, respectively. Antinociceptive activity of the extract (100 and 200 mg/kg) was significant in acetic acid-induced writhing test (53.33 and 54.57 %, inhibition) and the late phase of formalin test (88.04 % and 92.13 %, inhibition). No significant effect was found on motor performance in the open field. The GC-MS profile revealed the presence of 15 compounds, with cyclododecyne, hexadecanoic acid, ethyl ester, n-Hexadecanoic acid, (E)-9-Octadecenoic acid ethyl ester, 1,4,2,5 Cyclo-hexanetetrol and phytol, acetate as the main compounds.
CONCLUSION: F. paniculata demonstrated anti-inflammatory and antinociceptive effect and the anti-inflammatory mechanism could be through inhibition of the inflammatory markers and oxidative parameters.
AIM OF THE STUDY: The study aimed at evaluating the anti-inflammatory and antinociceptive effects of ethanol extract from the leaves of F. paniculata.
MATERIALS AND METHODS: The extract was obtained by maceration with ethanol (95 %) and characterized by GC-MS. The anti-inflammatory effect was assessed in carrageenan, serotonin, histamine-induced paw oedema and xylene-induced ear oedema models at the dose of 50, 100 and 200 mg/kg. Antioxidant parameters and cytokine production (IL-6, and TNF-α) levels were determined in carrageenan air pouch model. The antinociceptive property was also evaluated.
RESULTS: The extract at 200 mg/kg showed significant anti-inflammatory activity at 2 h (39.66 %, inhibition) which lasted for 5 h (70.37 %, inhibition) in carrageenan paw oedema. In the air pouch model, the extract decreased neutrophils and monocytes counts in the exudate but not lymphocytes count. At the dose of 200 mg/kg, the release of TNF-α and IL-6 was inhibited by 56.6 % and 35.9 %, respectively. The extract boosted catalase and SOD activities in addition to GSH level. Xylene-induced ear oedema was inhibited by 52.25, 62.62 and 64.97 %, at the dose of 50, 100 and 200 mg/kg, respectively. Antinociceptive activity of the extract (100 and 200 mg/kg) was significant in acetic acid-induced writhing test (53.33 and 54.57 %, inhibition) and the late phase of formalin test (88.04 % and 92.13 %, inhibition). No significant effect was found on motor performance in the open field. The GC-MS profile revealed the presence of 15 compounds, with cyclododecyne, hexadecanoic acid, ethyl ester, n-Hexadecanoic acid, (E)-9-Octadecenoic acid ethyl ester, 1,4,2,5 Cyclo-hexanetetrol and phytol, acetate as the main compounds.
CONCLUSION: F. paniculata demonstrated anti-inflammatory and antinociceptive effect and the anti-inflammatory mechanism could be through inhibition of the inflammatory markers and oxidative parameters.