Science (New York, N.Y.) · 2003
Control of effector CD8+ T cell function by the transcription factor Eomesodermin.
СтатьяПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
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Pearce Erika L, Mullen Alan C, Martins Gislâine A, Krawczyk Connie M, Hutchins Anne S, Zediak Valerie P, Banica Monica, DiCioccio Catherine B, Gross Darrick A, Mao Chai-An, Shen Hao, Cereb Nezih, Yang Soo Y, Lindsten Tullia, Rossant Janet, Hunter Christopher A, Reiner Steven L
Аннотация
Activated CD8+ T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8+ T cells. We now show that Eomesodermin (Eomes), a paralogue of T-bet, is induced in effector CD8+ T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8+ T cells, including interferon-gamma (IFN-gamma), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8+ T cells. We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity.
Предметные рубрики MeSH
Amino Acid SequenceAnimalsArenaviridae InfectionsBase SequenceCD8-Positive T-LymphocytesCell DifferentiationCytotoxicity, ImmunologicGene Expression RegulationGranzymesInterferon-gammaLymphocyte ActivationLymphocytic choriomeningitis virusMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLMolecular Sequence DataPerforinPore Forming Cytotoxic ProteinsRNA, MessengerSerine EndopeptidasesT-Box Domain ProteinsTh2 CellsTranscription FactorsT-bet Transcription Factor