[Biological evaluation of the effect of beta-lactam antibiotics on apoptosis in human lymphoid cells in vitro].

Models are developed that allow the effect of beta-lactam antibiotics on the level of apoptosis in human lymphoid cells to be evaluated in vitro. The antibiotics produced a dose-dependent decrease in apoptosis of mature lymphocytes both under normal conditions and in the state of dexamethasone-induced immunodepression. The beta-lactam antibiotics also affect the apoptosis in a pre-B-lymphoblast model. The dexamethasone-induced apoptosis is inhibited by beta-lactam antibiotics only in high doses.