Veterinary anaesthesia and analgesia · 2012
Naltrexone does not affect isoflurane minimum alveolar concentration in cats.
СтатьяРандомизированное исследованиеПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Brosnan Robert J, Pypendop Bruno H, Majewski-Tiedeken Chalon R, Shilo-Benjamini Yael, Ilkiw Jan E
Аннотация
OBJECTIVE: To test whether naltrexone, an opioid receptor antagonist, affects the minimum alveolar concentration (MAC) of isoflurane in cats, a species that is relatively resistant to the general anesthetic sparing effects of most opioids.
STUDY DESIGN: Randomized, crossover, placebo-controlled, blinded experimental design.
ANIMALS: Six healthy adult cats weighing 4.9 ± 0.7 kg.
METHODS: The cats were studied twice. In the first study, baseline isoflurane MAC was measured in duplicate. The drug (saline control or 0.6 mg kg(-1) naltrexone) was administered IV every 40-60 minutes, and isoflurane MAC was re-measured. In the second study, cats received the second drug treatment using identical methods 2 weeks later.
RESULTS: Isoflurane MAC was 2.03 ± 0.12% and was unchanged from baseline following saline or naltrexone administration.
CONCLUSION AND CLINICAL RELEVANCE: Minimum alveolar concentration was unaffected by naltrexone. Because MAC in cats is unaffected by at least some mu-opioid agonists and antagonists, spinal neurons that are directly modulated by mu-opioid receptors in this species cannot be the neuroanatomic sites responsible for immobility from inhaled anesthetics.
STUDY DESIGN: Randomized, crossover, placebo-controlled, blinded experimental design.
ANIMALS: Six healthy adult cats weighing 4.9 ± 0.7 kg.
METHODS: The cats were studied twice. In the first study, baseline isoflurane MAC was measured in duplicate. The drug (saline control or 0.6 mg kg(-1) naltrexone) was administered IV every 40-60 minutes, and isoflurane MAC was re-measured. In the second study, cats received the second drug treatment using identical methods 2 weeks later.
RESULTS: Isoflurane MAC was 2.03 ± 0.12% and was unchanged from baseline following saline or naltrexone administration.
CONCLUSION AND CLINICAL RELEVANCE: Minimum alveolar concentration was unaffected by naltrexone. Because MAC in cats is unaffected by at least some mu-opioid agonists and antagonists, spinal neurons that are directly modulated by mu-opioid receptors in this species cannot be the neuroanatomic sites responsible for immobility from inhaled anesthetics.