Materials science & engineering. C, Materials for biological applications · 2017
Innovative material containing the natural product curcumin, with enhanced antimicrobial properties for active packaging.
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Papadimitriou A, Ketikidis I, Stathopoulou M-E K, Banti C N, Papachristodoulou C, Zoumpoulakis L, Agathopoulos S, Vagenas G V, Hadjikakou S K
Аннотация
Curcumin (Curc) reacts with zinc di‑iodine (ZnI2) in 2:1molar ratio in the presence of an excess of a base triethylamine ((CH3CH2)3N) in methanol (CH3OH) solution towards the amorphous solid material of formula [ZnI2(Curc)2] (1). The complex was characterized by melting point (m.p.), Fourier Transform-Infra Red (FT-IR) and Nuclear Magnetic Resonance of hydrogen nucleus (1H NMR) spectroscopy. The formula of 1 was determined by X-ray fluorescence (XRF) analysis. The retention of the structure in solution was confirmed by 1H NMR spectroscopy. The antimicrobial activity of the complex has been studied against the bacteria Pseudomonas aeruginosa (PAO1). The Minimum Inhibitory Concentrations (MIC) of the compounds 1 and Curc against P. aeruginosa (PAO1) are: 71.3μΜ (75.3μg/mL) for [ZnI2(Curc)2] and 339μM (125μg/mL) for Curc, respectively. Moreover, the antimicrobial activity of the new material which was diffused in polystyrene against biofilm formed by PAO1 was also calculated.