Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2011
Psychological stress induces alterations in temporomandibular joint ultrastructure in a rat model of temporomandibular disorder.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Wu Gaoyi, Chen Lei, Zhu Guoxiong, Su Yucheng, Chen Yongjin, Sun Jing, Wang Yanliang
Аннотация
OBJECTIVE: The objective of this study was to investigate the effects of psychological stress on temporomandibular disorder (TMD).
STUDY DESIGN: A communication box was used to induce psychological stress (PS) in rats. Then, the ultrastructure of temporomandibular was observed using scanning electron microscopy. Interleukin-1 (IL-1) and IL-6 were measured with reverse transcription polymerase chain reaction.
RESULTS: The PS group showed evidence of ultrastructural changes in the condyle and articular disk after stimulation, i.e., incomplete gelatinlike material was observed on the condyle after 1 week of PS, wider waves on the articular disk and exposed condylar collagen were observed after 3 weeks of PS, and cracks were apparent on the surface of the condyle. The expression of IL-1 and IL-6 in the condyle cartilage significantly increased after exposure to psychological stress.
CONCLUSIONS: These results indicate that psychological stress induces ultrastructure alterations in the temporomandibular joint and plays an important role in TMD.
STUDY DESIGN: A communication box was used to induce psychological stress (PS) in rats. Then, the ultrastructure of temporomandibular was observed using scanning electron microscopy. Interleukin-1 (IL-1) and IL-6 were measured with reverse transcription polymerase chain reaction.
RESULTS: The PS group showed evidence of ultrastructural changes in the condyle and articular disk after stimulation, i.e., incomplete gelatinlike material was observed on the condyle after 1 week of PS, wider waves on the articular disk and exposed condylar collagen were observed after 3 weeks of PS, and cracks were apparent on the surface of the condyle. The expression of IL-1 and IL-6 in the condyle cartilage significantly increased after exposure to psychological stress.
CONCLUSIONS: These results indicate that psychological stress induces ultrastructure alterations in the temporomandibular joint and plays an important role in TMD.
Предметные рубрики MeSH
Adrenocorticotropic HormoneAnimalsAnti-Anxiety AgentsCartilage, ArticularCollagenDiazepamDisease Models, AnimalHydrocortisoneInterleukin-1Interleukin-6MaleMandibular CondyleMicroscopy, Electron, ScanningRandom AllocationRatsRats, WistarReverse Transcriptase Polymerase Chain ReactionStress, PsychologicalSynovial MembraneTemporomandibular JointTemporomandibular Joint DiscTemporomandibular Joint DisordersTime Factors