Treatment of reflux oesophagitis. A randomized, controlled evaluation of cimetidine.

Twenty-five patients were studied in an eight-week randomized controlled comparison of cimetidine and placebo in the treatment of reflux oesophagitis. Therapy with cimetidine (1.0 g/day), compared with placebo, did not produce a statistically significant beneficial effect as assessed by relief of heartburn, reduction in antacid use, endoscopic evidence of healing, histological signs of improvement, or response to the acid perfusion (Bernstein) test.