Avicenna journal of phytomedicine · 2012
Evaluation of the anti-depressant activity of Myristica fragrans (Nutmeg) in male rats.
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Moinuddin Ghulam, Devi Kshama, Kumar Khajuria Deepak
Аннотация
OBJECTIVE: The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans (MS).
MATERIALS AND METHODS: Male Wistar rats were subjected to imipramine and herbal extract of MS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST).
RESULTS: Administration of MS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to the control group. However, there was no significant potentiation of PST.
CONCLUSION: Our study demonstrated the potential antidepressant activity of MS.
MATERIALS AND METHODS: Male Wistar rats were subjected to imipramine and herbal extract of MS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST).
RESULTS: Administration of MS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to the control group. However, there was no significant potentiation of PST.
CONCLUSION: Our study demonstrated the potential antidepressant activity of MS.