Aging medicine (Milton (N.S.W)) · 2025
Patchouli Ethanol Extract Pogostemon cablin Benth. Against Aging Profiles in Doxorubicin-Induced 3T3-L1 Fibroblast Cell Lines.
СтатьяНазвание и аннотация: Перевод в очереди
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Santoso Teguh, Khairani Astrid Feinisa, Bashari Muhammad Hasan, Ramadhanti Julia, Rohmawati Enny, Oktora Monika Pury, Wiraswati Hesti Lina
Аннотация
OBJECTIVES: This research aimed to investigate the potential of Pogostemon cablin Benth's ethanolic extract (PCEE) as an antiaging agent.
METHODS: We treated 3T3-L1 cells induced by doxorubicin with PCEE and assessed them with antiaging markers such as GLB-1 gene and telomere length with polymerase chain reaction (PCR), or reactive oxygen species (ROS) accumulation with 2,7-dichlorofluorescein diacetate (DCFHDA).
RESULTS: This study demonstrates that PCEE can inhibit ROS accumulation, decrease the expression level of the senescence-associated β-galactosidase (SA-β-gal) gene, GLB-1, and maintain telomere length in doxorubicin-induced 3T3-L1 cells.
CONCLUSION: These studies reveal that PCEE is a promising antiaging agent. An in vivo approach should be conducted for further research.
METHODS: We treated 3T3-L1 cells induced by doxorubicin with PCEE and assessed them with antiaging markers such as GLB-1 gene and telomere length with polymerase chain reaction (PCR), or reactive oxygen species (ROS) accumulation with 2,7-dichlorofluorescein diacetate (DCFHDA).
RESULTS: This study demonstrates that PCEE can inhibit ROS accumulation, decrease the expression level of the senescence-associated β-galactosidase (SA-β-gal) gene, GLB-1, and maintain telomere length in doxorubicin-induced 3T3-L1 cells.
CONCLUSION: These studies reveal that PCEE is a promising antiaging agent. An in vivo approach should be conducted for further research.