The Annals of thoracic surgery · 2006
ACTH-secreting thymic carcinoid associated with multiple endocrine neoplasia type 1.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Yano Motoki, Fukai Ichiro, Kobayashi Yoshihiro, Mizuno Kotaro, Konishi Akimitsu, Haneda Hiroshi, Suzuki Eriko, Endo Katsuhiko, Fujii Yoshitaka
Аннотация
Thymic carcinoids are classified into three categories: (1) nonsecretory tumors, (2) hormonal secretory tumors, and (3) tumors associated with multiple endocrine neoplasia type 1. We report a rare case with adrenocorticotropic hormone secreting thymic carcinoid with multiple endocrine neoplasia type 1. Radiologic examination showed an anterior mediastinal mass and a parathyroid tumor. Blood analysis revealed high levels of parathyroid hormone and adrenocorticotropic hormone. Urine cortisol and 17-hydroxycorticoids levels were also elevated. Extended thymectomy was performed. Subsequently adjuvant radiation therapy and parathyroid tumor resection were performed. A germline mutation of exon 7 in the multiple endocrine neoplasia type 1 gene was detected and a somatic mutation of exon 9 was demonstrated in the thymic tumor.
Предметные рубрики MeSH
ACTH Syndrome, EctopicAntineoplastic Agents, HormonalCarcinoid TumorCombined Modality TherapyDNA Mutational AnalysisDNA, NeoplasmExonsFlushingGenes, Tumor SuppressorHumansHypercalcemiaMaleMiddle AgedMultiple Endocrine Neoplasia Type 1OctreotideParathyroid HormoneParathyroid NeoplasmsParathyroidectomyPleural NeoplasmsRadiotherapy, AdjuvantThymectomyThymus Neoplasms