Journal of Asian natural products research · 2024
A new canthinone glycoside isolated from the root barks of Ailanthus altissima with NO inhibitory activity.
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Xue Jin-Feng, Zhao Chen-Guang, Pan Hao, Duan Jiang-Jing, Jia Yao-Yao, Chen Hui, Feng Wei-Sheng, Xue Gui-Min
Аннотация
One new canthinone glycoside (1), together with six known compounds (2-7) including three lignans (2-4), two coumarins (5-6) and one phenol (7) was isolated from the root barks of Ailanthus altissima. The structure of new compound 1 was established by the interpretation of UV, IR, MS and NMR data, while its absolute configuration was determined by acid hydrolysis and GIAO NMR calculations with DP4+ probability analysis. The inhibitory effects of all compounds on Nitric oxide (NO) production were investigated in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Results showed that compounds 2 and 5 displayed NO production inhibitory activity with IC50 values of 30.1 and 15.3 μM, respectively.