Clinical biochemistry · 2012
Streptomycin interference in Jaffe reaction - possible false positive creatinine estimation in excessive dose exposure.
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Syal Kirtimaan, Srinivasan Anand, Banerjee Dibyajyoti
Аннотация
OBJECTIVES: To study the potential of commonly used aminoglycoside antibiotics to form non-creatinine chromogen with alkaline picrate reagent.
DESIGN AND METHODS: We studied the non-creatinine chromogen formation of various concentrations of streptomycin, amikacin, kanamycin, netilmicin, gentamicin and tobramycin added to known creatinine concentrations by the Jaffe reaction based creatinine estimation.
RESULTS: Only streptomycin above therapeutic concentrations of 10mg/mL interfered in the Jaffe reaction and acted as non-creatinine chromogen.
CONCLUSIONS: Therapeutic doses of the aminoglycosides do not form non-creatinine chromogens.
DESIGN AND METHODS: We studied the non-creatinine chromogen formation of various concentrations of streptomycin, amikacin, kanamycin, netilmicin, gentamicin and tobramycin added to known creatinine concentrations by the Jaffe reaction based creatinine estimation.
RESULTS: Only streptomycin above therapeutic concentrations of 10mg/mL interfered in the Jaffe reaction and acted as non-creatinine chromogen.
CONCLUSIONS: Therapeutic doses of the aminoglycosides do not form non-creatinine chromogens.