Occurrence and ecotoxicity of sulfonamides in the aquatic environment: A review.

Rapid population growth and increasing demand for animal protein food have led to a continuous increase in global utilization of antibiotic. Sulfonamides (SAs) are ubiquitous in aquatic environments and pose an ecological risk owing to their large consumption and strong environmental persistence. Hence, this review focuses on the recent publications on 12 different SAs and provides a detailed summary of selected antibiotic concentrations in various water systems. We evaluated the ecotoxicity of SAs on organisms at different trophic level organisms and the environmental risks regarding aquatic systems. The results indicated that SA antibiotics were ubiquitous in aquatic environments at concentrations ranging from ng/L to μg/L. According to the data using standard ecotoxicity bioassays, algae were the most susceptible aquatic organisms for selected antibiotics, followed by crustaceans and fish. The risk data suggested that some antibiotics, such as sulfadiazine (SDZ), sulfamethoxazole (SMX), and sulfamethazine (SMZ) pose a great risk to the aquatic system. Based on the present review, it is necessary to strengthen the research into their ecotoxicity to marine systems and the chronic toxicity of antibiotic mixtures.