Decalin-type acetylcholine-mimetic organophosphates as inhibitors of acetylcholinesterase.

The novel decalin-type N,O,P-heterocycles, P(3)-axially and P(3)-equatorially substituted cis- and trans-configurated 3-fluoro-2,4-dioxa-7-aza-, 2,4-dioxa-8-aza-, and 2,4-dioxa-9-aza-3-phosphabicyclo[4.4.0]decane 3-oxides, are configuratively fixed and conformationally constrained phosphorus analogues of acetylcholine. The compounds are suitable probes for the investigation of molecular interactions with acetylcholinesterase.