Heterotopic development of DMBA subcutaneous sarcoma in rats.

In gonadectomized and totally or partially criptorchid rats, subcutaneous inoculation of 0,5 mg of DMBA often determines the development of sarcomas at variable, sometimes marked, distances from the site of inoculation. The phenomenon is exhibited maximally in rats subjected to unilateral cryptorchidism or to unilateral gonadectomy; in minimal measure in those subjected to bilateral gonadectomy. It is not exhibited in the intact animals. The Authors, though presenting several hypotheses, are not able to furnish a satisfactory explanation of the phenomenon.