American journal of obstetrics and gynecology · 2012
Transplacental transfer of vancomycin and telavancin.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Nanovskaya Tatiana, Patrikeeva Svetlana, Zhan Ying, Fokina Valentina, Hankins Gary D V, Ahmed Mahmoud S
Аннотация
OBJECTIVE: We sought to determine the bidirectional transfer and distribution of vancomycin and telavancin across the dually perfused term human placental lobule.
STUDY DESIGN: The technique of dually perfused placental lobule was used in its recirculating mode to determine the maternal to fetal (M→F) (n = 20) and fetal to maternal (n = 18) transfer of each antibiotic, which were coperfused with their radioactive isotopes. The concentrations of drugs were determined by liquid scintillation spectrometry.
RESULTS: In the M→F direction, the transfer of vancomycin (9.6 ± 4%) and telavancin (6.5 ± 2%) were low; however, telavancin retention by the perfused lobule was greater than that of vancomycin (P < .01). The normalized transplacental transfer of telavancin across the placental lobule in the fetal to maternal direction was higher than in the M→F direction (P < .01), suggesting the involvement of placental efflux transporters.
CONCLUSION: The ex vivo perfusion experiments revealed low transfer of vancomycin and telavancin to the fetal circuit.
STUDY DESIGN: The technique of dually perfused placental lobule was used in its recirculating mode to determine the maternal to fetal (M→F) (n = 20) and fetal to maternal (n = 18) transfer of each antibiotic, which were coperfused with their radioactive isotopes. The concentrations of drugs were determined by liquid scintillation spectrometry.
RESULTS: In the M→F direction, the transfer of vancomycin (9.6 ± 4%) and telavancin (6.5 ± 2%) were low; however, telavancin retention by the perfused lobule was greater than that of vancomycin (P < .01). The normalized transplacental transfer of telavancin across the placental lobule in the fetal to maternal direction was higher than in the M→F direction (P < .01), suggesting the involvement of placental efflux transporters.
CONCLUSION: The ex vivo perfusion experiments revealed low transfer of vancomycin and telavancin to the fetal circuit.