Veterinary anaesthesia and analgesia · 2019
Comparative evaluation of sedative and clinical effects of dexmedetomidine and xylazine in dromedary calves (Camelus dromedarius).
СтатьяRandomized Controlled Trial, VeterinaryНазвание и аннотация: Перевод в очереди
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Samimi Amir S, Molaei Mohammad M, Azari Omid, Ebrahimpour Fatemeh
Аннотация
OBJECTIVE: To compare the sedative and clinical effects of intravenous (IV) administration of dexmedetomidine and xylazine in dromedary calves.
STUDY DESIGN: Experimental, crossover, randomized, blinded study.
ANIMALS: A total of seven healthy male dromedary calves aged 14 ± 2 weeks and weighing 95 ± 5.5 kg.
METHODS: Calves were assigned three IV treatments: treatment XYL, xylazine (0.2 mg kg-1); treatment DEX, dexmedetomidine (5 μg kg-1); and control treatment, normal saline (0.01 mL kg-1). Sedation scores, heart rate (HR), respiratory rate (fR), rectal temperature (RT) and ruminal motility were recorded before (baseline) and after drug administration. Sedation signs were scored using a 4-point scale. One-way anova and Mann-Whitney U tests were used for data analysis.
RESULTS: Calves in treatments XYL and DEX were sedated at 5-60 minutes. Sedation had waned in XYL calves, but not DEX calves, at 60 minutes (p = 0.037). Sedation was not present in calves of any treatment at 90 minutes. HR decreased from baseline in XYL and DEX at 5-90 minutes after drug administration and was lower in DEX than XYL at 5 minutes (p = 0.017). HR was lower in DEX (p = 0.001) and XYL (p = 0.013) than in control treatment at 90 minutes. fR decreased from baseline in XYL and DEX at 5-60 minutes after drug administration and was lower in DEX than XYL at 5 minutes (p = 0.013). RT was unchanged in any treatment over 120 minutes. Ruminal motility was decreased in XYL at 5, 90 and 120 minutes and absent at 10-60 minutes. Motility was decreased in DEX at 5, 10 and 120 minutes and was absent at 15-90 minutes.
CONCLUSION AND CLINICAL RELEVANCE: The duration of sedation from dexmedetomidine (5 μg kg-1) and xylazine (0.2 mg kg-1) was similar in dromedary calves.
STUDY DESIGN: Experimental, crossover, randomized, blinded study.
ANIMALS: A total of seven healthy male dromedary calves aged 14 ± 2 weeks and weighing 95 ± 5.5 kg.
METHODS: Calves were assigned three IV treatments: treatment XYL, xylazine (0.2 mg kg-1); treatment DEX, dexmedetomidine (5 μg kg-1); and control treatment, normal saline (0.01 mL kg-1). Sedation scores, heart rate (HR), respiratory rate (fR), rectal temperature (RT) and ruminal motility were recorded before (baseline) and after drug administration. Sedation signs were scored using a 4-point scale. One-way anova and Mann-Whitney U tests were used for data analysis.
RESULTS: Calves in treatments XYL and DEX were sedated at 5-60 minutes. Sedation had waned in XYL calves, but not DEX calves, at 60 minutes (p = 0.037). Sedation was not present in calves of any treatment at 90 minutes. HR decreased from baseline in XYL and DEX at 5-90 minutes after drug administration and was lower in DEX than XYL at 5 minutes (p = 0.017). HR was lower in DEX (p = 0.001) and XYL (p = 0.013) than in control treatment at 90 minutes. fR decreased from baseline in XYL and DEX at 5-60 minutes after drug administration and was lower in DEX than XYL at 5 minutes (p = 0.013). RT was unchanged in any treatment over 120 minutes. Ruminal motility was decreased in XYL at 5, 90 and 120 minutes and absent at 10-60 minutes. Motility was decreased in DEX at 5, 10 and 120 minutes and was absent at 15-90 minutes.
CONCLUSION AND CLINICAL RELEVANCE: The duration of sedation from dexmedetomidine (5 μg kg-1) and xylazine (0.2 mg kg-1) was similar in dromedary calves.