Immunohistochemical demonstration of viral antigens in paraffin embedded autopsy specimens of virally infected central nervous system.

Viral antigens are preserved in routinely processed and paraffin embedded CNS tissue to an extent that they can be traced by the highly sensitive and specific unlabeled antibody method. Using this method, it was possible to visualize antigens of measles, influenza A, polio, varicella-zoster, herpes simplex, cytomegalo, parainfluenza I, lymphocytic choriomeningitis, Moloney, and Friend virus.