Localized unilateral periorbital edema induced by aspirin.

BACKGROUND

Aspirin intolerance manifested as bronchospasm or urticaria/angioedema has been observed since the beginning of this century.

OBJECTIVE

To report a novel case of intolerance to aspirin ingestion.

METHODS

Case report; routine skin testing; pulmonary function testing; aspirin challenge.

RESULTS

A 30-year-old man with a history of left ocular trauma at the age of 10 noted a 3-year history of left periorbital angioedema after aspirin but not other nonsteroidal anti-inflammatory drugs. Incremental oral aspirin challenge resulted in this unilateral symptomatology at a dose of 673 mg.

CONCLUSION

To the best of our knowledge, this is the first reported case of unilateral periorbital edema following aspirin ingestion.