Acute myocardial infarction in a patient with von Willebrand disease.

Coronary atherosclerosis is uncommon in patients with von Willebrand factor deficiency. Occurrence of acute myocardial infarction is even rarer in these patients. We report on a 69-year-old woman with a long-standing history of von Willebrand disease who presented with acute myocardial infarction. Thrombolytic therapy with rtPA, heparin, and aspirin, followed by percutaneous transluminal coronary angioplasty and coronary stenting, was performed without significant bleeding or other complications.