Emerging infectious diseases · 2013
Microevolution of highly pathogenic avian influenza A(H5N1) viruses isolated from humans, Egypt, 2007-2011.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Younan Mary, Poh Mee Kian, Elassal Emad, Davis Todd, Rivailler Pierre, Balish Amanda L, Simpson Natosha, Jones Joyce, Deyde Varough, Loughlin Rosette, Perry Ije, Gubareva Larisa, ElBadry Maha A, Truelove Shaun, Gaynor Anne M, Mohareb Emad, Amin Magdy, Cornelius Claire, Pimentel Guillermo, Earhart Kenneth, Naguib Amel, Abdelghani Ahmed S, Refaey Samir, Klimov Alexander I, Donis Ruben O, Kandeel Amr
Аннотация
We analyzed highly pathogenic avian influenza A(H5N1) viruses isolated from humans infected in Egypt during 2007-2011. All analyzed viruses evolved from the lineage of subtype H5N1 viruses introduced into Egypt in 2006; we found minimal evidence of reassortment and no exotic introductions. The hemagglutinin genes of the viruses from 2011 formed a monophyletic group within clade 2.2.1 that also included human viruses from 2009 and 2010 and contemporary viruses from poultry; this finding is consistent with zoonotic transmission. Although molecular markers suggestive of decreased susceptibility to antiviral drugs were detected sporadically in the neuraminidase and matrix 2 proteins, functional neuraminidase inhibition assays did not identify resistant viruses. No other mutations suggesting a change in the threat to public health were detected in the viral proteomes. However, a comparison of representative subtype H5N1 viruses from 2011 with older subtype H5N1 viruses from Egypt revealed substantial antigenic drift.