Determination of sulfonamides in meat by monolithic covalent organic frameworks based solid phase extraction coupled with high-performance liquid chromatography-mass spectrometric.

In this work, hierarchical porous covalent organic frameworks (HP-COFs) foam, named as HP-TpBD, was prepared by using 1,3,5-trimethylphloroglucinol (Tp) and benzidine (BD) as building blocks under the assistant of NaCl template. Its potential application as the sorbent for solid phase extraction (SPE) of sulfonamides (SAs) in meat products were explored by coupling with high performance liquid chromatography-mass spectrum (HPLC-MS) analysis. The key factors affecting extraction efficiency were well studied. Under the optimum conditions, the proposed method exhibited high preconcentration factors of 100, low limit of detection (0.10-0.23 μg/kg), and wide linear ranges (0.5-200 μg/kg). In addition, the determination of SAs in real samples were realized with satisfactory recoveries (82.8-119.9%), demonstrating the applicability of the proposed method. The easy operation, superior extraction affinity and good recycle performance demonstrated the resulting HP-COF foam is a promising adsorbent for the preconcentration of trace organic compounds from complex matrix.