Science (New York, N.Y.) · 2018
Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes.
СтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Zhao Liping, Zhang Feng, Ding Xiaoying, Wu Guojun, Lam Yan Y, Wang Xuejiao, Fu Huaqing, Xue Xinhe, Lu Chunhua, Ma Jilin, Yu Lihua, Xu Chengmei, Ren Zhongying, Xu Ying, Xu Songmei, Shen Hongli, Zhu Xiuli, Shi Yu, Shen Qingyun, Dong Weiping, Liu Rui, Ling Yunxia, Zeng Yue, Wang Xingpeng, Zhang Qianpeng, Wang Jing, Wang Linghua, Wu Yanqiu, Zeng Benhua, Wei Hong, Zhang Menghui, Peng Yongde, Zhang Chenhong
Аннотация
The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, to show that a select group of SCFA-producing strains was promoted by dietary fibers and that most other potential producers were either diminished or unchanged in patients with T2DM. When the fiber-promoted SCFA producers were present in greater diversity and abundance, participants had better improvement in hemoglobin A1c levels, partly via increased glucagon-like peptide-1 production. Promotion of these positive responders diminished producers of metabolically detrimental compounds such as indole and hydrogen sulfide. Targeted restoration of these SCFA producers may present a novel ecological approach for managing T2DM.