Life sciences · 2013
Effects of cilnidipine on sympathetic outflow and sympathetic arterial pressure and heart rate regulations in rats.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Yamamoto Hiromi, Kawada Toru, Shimizu Shuji, Kamiya Atsunori, Miyazaki Shunichi, Sugimachi Masaru
Аннотация
AIMS: Cilnidipine is a unique Ca(2+) channel blocker that inhibits both L-type and N-type Ca(2+) channels. The present study aimed to assess the effects of intravenous cilnidipine on sympathetic outflow and sympathetic arterial pressure (AP) and heart rate (HR) regulations.
MAIN METHODS: Carotid sinus baroreceptor regions were isolated from the systemic circulation in anesthetized and vagotomized Wistar Kyoto rats. Changes in efferent sympathetic nerve activity (SNA), AP and HR in response to a stepwise input of carotid sinus pressure were examined before and during intravenous cilnidipine administration (30 μg/kg bolus+100 μg kg(-1)h(-1) infusion, n=6).
KEY FINDINGS: Cilnidipine significantly reduced the AP response range (from 68.0 ± 10.2 to 34.6 ± 4.1 mmHg, P=0.007) but did not affect the SNA response range (from 90.4 ± 10.3 to 84.7 ± 9.5%, P=0.297) or the HR response range (from 50.4 ± 10.1 to 48.1 ± 6.2 beats/min, P=0.719).
SIGNIFICANCE: Cilnidipine, at a depressor dose used in the present study, does not acutely suppress sympathetic outflow from the central nervous system. Also, it spared the sympathetic HR response, suggesting that N-type Ca(2+) channel blocking action at the cardiac sympathetic nerve endings may be a modest one.
MAIN METHODS: Carotid sinus baroreceptor regions were isolated from the systemic circulation in anesthetized and vagotomized Wistar Kyoto rats. Changes in efferent sympathetic nerve activity (SNA), AP and HR in response to a stepwise input of carotid sinus pressure were examined before and during intravenous cilnidipine administration (30 μg/kg bolus+100 μg kg(-1)h(-1) infusion, n=6).
KEY FINDINGS: Cilnidipine significantly reduced the AP response range (from 68.0 ± 10.2 to 34.6 ± 4.1 mmHg, P=0.007) but did not affect the SNA response range (from 90.4 ± 10.3 to 84.7 ± 9.5%, P=0.297) or the HR response range (from 50.4 ± 10.1 to 48.1 ± 6.2 beats/min, P=0.719).
SIGNIFICANCE: Cilnidipine, at a depressor dose used in the present study, does not acutely suppress sympathetic outflow from the central nervous system. Also, it spared the sympathetic HR response, suggesting that N-type Ca(2+) channel blocking action at the cardiac sympathetic nerve endings may be a modest one.