The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2011
Management and treatment of hepatitis B virus in patients with HIV infection: A practical guide for health care professionals.
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Klein Marina B, Baril Jean-Guy, Charron Marc-André, Fortin Claude, Lalonde Richard, Matte Marie-France, Poliquin Marc, Talbot Annie, Therrien Rachel, Tremblay Cécile, Trottier Benoît, Tsarevsky Irina, Villeneuve Jean-Pierre
Аннотация
The management and treatment of HIV and hepatitis B virus (HBV)-coinfected patients present specific challenges for clinicians. The morbidity and mortality related to these concomitant infections are growing concerns, while the use of antiviral drugs effective against both viruses complicates therapeutic decision making. The present document provides guidelines for physicians regarding care and treatment of patients coinfected with HIV and HBV. Primary prevention of HBV in HIV-positive patients is achieved through appropriate vaccination schedules. Follow-up before treatment of HBV may include liver biopsy, screening for hepatocellular carcinoma and testing for esophageal varicies in cases of cirrhosis. In HBV-infected patients requiring treatment, recommendations regarding initiation, duration and choice of first-line drugs are made. Finally, in the case of resistance, appropriate alternative therapies are necessary.