Interaction of povidone with aromatic compounds V: Relationship of binding tendency in a macromolecular solution treated as a pseudo two phase and a monophase.

The pseudo-two-phase model is proposed to correlate complex formation of ligand molecules with povidone with partition coefficients (log P or II constants). The conditions which permit the use of the pseudo-two-phase model for binding of ligand onto macromolecules are determined. This model seems to be a more rational choice than the frequently used complex formation model (monophase). This is demonstrated theoretically and confirmed experimentally. The advantages of the use of such a model are also discussed.