Copper-Catalyzed Oxidative C-H Bond Functionalization of N-Allylbenzamide for Regioselective C-N and C-O Bond Formation.

Copper-catalyzed oxidative couplings of N-allylbenzamides for C-N and C-O bond formations have been developed through C-H bond functionalization. To demonstrate the utility of this approach, it was applied to the synthesis of β-aminoimides and imides. To the best of our knowledge, these are the first examples in which different classes of N-containing compounds have been directly prepared from the readily available N-allylbenzamides using an inexpensive catalyst/oxidant/base (CuSO4 /TBHP/Cs2 CO3 ) system.