The Journal of cardiovascular surgery · 1976
Activity of sympathetic nerves in heart during cardiopulmonary bypass in patients.
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Barta E, Kuzela L, Kvetnansky R, Siska K, Babusikova F, Torda M, Cornak V, Horecky J
Аннотация
The sympathetic nerve activity in heart during cardiopulmonary bypass was studied in 20 patients. The rate of release of dopamine-beta-hydroxylase from cardiac nerves was used as an indicator. It was found that the thoracotomy alone does not represent such a stimulus which would lead unambiguously to sympathetic overactivity in heart. Cardiopulmonary bypass represents, on the other hand, an intensive sympathomimetic stimulus, as it was demonstrated by significnat increase of coronary A-V difference negativity of dopamine-beta-hydroxylase as early in 15th minute of its duration. The washout of enzyme to the end of 30 min. duration of bypass still increased. After finishing of bypass the coronary A-V diff. of dopamine-beta-hydroxylase again decreased.