[Acute experimental (endogenous) hepatic coma and the clinical syndrome of acute hepatocellular injury].

In search of the adequate experimental model for creating endogenous coma, the characteristics of which would be identical to the clinical picture of acute hepatic coma in men, the ischaemic method of experimentally originated acute endogenous hepatic coma was applied. The experiment was carried out on 12 dogs in which the terminolateral portocaval shunt with ligation of all the collateral of the arterial irrigation leading to the liver was performed, while the double ligation was performed on the hepatic artery. After the animals had emerged from the postoperative state of shock, the hepatic artery was ligated in local anesthesia and the created state was controlled by clinical observations and laboratory tests. Experimentally created acute endogenous hepatic coma achieved by applying ischaemic method proved to be a good model. Its true value manifested itself in the clinical picture as well as in the laboratory findings which resembled considerably the state of acute hepatic coma in men.