The Annals of otology, rhinology, and laryngology · 1993
Histamine metabolism in nasal polyps.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Ogino S, Abe Y, Irifune M, Harada T, Matsunaga T, Imamura I, Fukui H
Аннотация
We attempted to determine the relationship of nasal polyps to histamine (HA) metabolism. Compared to that in allergy-related nasal polyps and infection-related nasal polyps, the level of HA in aspirin-induced asthma-related polyps was significantly lower. Large differences between the groups were not observed in HA-synthesizing enzyme activity, but degradative enzyme activity was much higher in aspirin-induced asthma-related polyps than in other types of nasal polyps tested. These findings suggest the possibility that the amount of HA in polyps associated with aspirin-induced asthma was less because of greatly enhanced degradation. We found, in addition, that in nasal tissues such as polyps, histamine-N-methyl transferase, rather than histaminase, was the principal degradative enzyme.