Anticancer research · 2018
Antiproliferative and Apoptotic Role of Novel Synthesized Cu(II) Complex with 3-(3-(4-fluorophenyl)Triaz-1-en-1-yl) Benzenesulfonamide in Common Cancer Models.
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Tuluce Yasin, Gorgisen Gokhan, Gulacar Ismail Musab, Koyuncu Ismail, Durgun Mustafa, Akocak Suleyman, Ozkol Halil, Kaya Zehra
Аннотация
BACKGROUND/AIM: Chemotherapeutic treatment options are often ineffective due to the development of resistance in cancer cells. Therefore, developing new anti-cancer agents is crucial for cancer treatment. Some triazine derivatives, their complexes and Copper(II) have anti-cancer effects on cancer cells. In this study, we aimed to determine the anti-proliferative effect of the novel synthesized Cu(II) complex with 3-(3-(4-fluorophenyl)triaz-1-en-1-yl) benzene-sulfonamide compound on the common cancer cell lines HeLa, MDA-MB-231, A2780 and MCF7.
MATERIALS AND METHODS: Common cancers cell lines were treated with copper complexes. Cell viability and apoptotic gene expression were examined.
RESULTS: Novel synthesized copper complex led to decreased viability of all cell lines. It also induced apoptosis via increasing the expression of caspase-3, caspase-9, Bax and p53 proteins and decreasing ERK expression.
CONCLUSION: The novel synthesized copper complex has a significant inhibitory effect on the viability of cancer cell lines and can be considered as an antitumor agent for further studies.
MATERIALS AND METHODS: Common cancers cell lines were treated with copper complexes. Cell viability and apoptotic gene expression were examined.
RESULTS: Novel synthesized copper complex led to decreased viability of all cell lines. It also induced apoptosis via increasing the expression of caspase-3, caspase-9, Bax and p53 proteins and decreasing ERK expression.
CONCLUSION: The novel synthesized copper complex has a significant inhibitory effect on the viability of cancer cell lines and can be considered as an antitumor agent for further studies.