Brain & development · 2012
A pediatric patient with myopathy associated with antibodies to a signal recognition particle.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Kawabata Takayoshi, Komaki Hirofumi, Saito Takashi, Saito Yoshiaki, Nakagawa Eiji, Sugai Kenji, Sasaki Masayuki, Hayashi Yukiko K, Nishino Ichizo, Momomura Mei, Kizawa Toshitaka, Imagawa Tomoyuki, Yokota Shumpei
Аннотация
We report the case of a 15-year-old Japanese girl with myopathy associated with antibodies to a signal recognition particle (anti-SRP myopathy). The patient presented with progressive symmetrical proximal muscle weakness that caused difficulty in walking within 3 months, and marked elevation of the serum creatine kinase levels. A skeletal muscle biopsy revealed active necrotic and regenerating processes, with mild inflammatory changes. Based on the above findings, the patient was diagnosed as having anti-SRP myopathy. Only a limited number of pediatric patients with anti-SRP myopathy has been reported previously, with usually a poor prognosis. Early diagnosis is important for obtaining a better prognosis in patients with anti-SRP myopathy.