The reaction of N-iodosuccinimide with the goitrogens: a model for the active iodine of the thyroid gland.

The reactivities of N-iodosuccinimide and iodine with various goitrogenic compounds were studied with dimethylsulfoxide through which nitrogen had been bubbled as a solvent. Although iodine does not react with all of the compounds, N-iodosuccinimide does react with all of them. N-Iodosuccinimide may, therefore, serve as an interesting model for the "active iodine" of the thyroid.