[Adipocytic Endogenous Hydrogen Sulfide-Function,Regulation and Diseases].

Hydrogen sulfide (H2S)is a novel gastrotransmitter, and plays a protective role in many diseases. Adipocyte endogenously produces H2S by cystathionine β synthase (CBS), cystathionine γ lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MPST).The endogenous H2S in adipocyte plays an essential role in glucose uptake activity and utilization, lipolysis and adipocyte differentiation, and then takes part in the pathogenesis of obesity, diabetes and cardiovascular diseases.H2S regulates adipocyte energy metabolism by activation activating insulin receptor, peroxisome proliferator activated receptor γ (PPARγ) or potassium channel. H2S acts as an "energy switch" in regulation of metabolic diseases.