Clinical and experimental hypertension (New York, N.Y. : 1993) · 2012
Effects of cilnidipine on serum uric acid level and urinary nitrogen monoxide excretion in patients with hypertension.
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Hamada Toshihiro, Yamada Kensaku, Mizuta Einosuke, Watanabe Arisa, Osaki Tomohiro, Ishida Katsunori, Hasegawa Akira, Sakata Shinji, Mishima Mutsuo, Ogino Kazuhide, Nosaka Yoshihito, Miyazaki Satoshi, Ohtahara Akira, Ninomiya Haruaki, Kato Masahiko, Yoshida Akio, Taniguchi Shin-ichi, Yamamoto Kazuhiro, Hisatome Ichiro
Аннотация
The effects of cilnidipine on the serum uric acid level and urinary NO excretion in hypertensive patients were investigated. Blood and urine samples of 16 hypertensive outpatients were collected before and 2 months after cilnidipine therapy (10 mg). The serum uric acid level decreased significantly after cilnidipine treatment, while the uric acid-creatinine clearance ratio was unaffected. The cilnidipine medication produced a significant increase in urinary NO excretion, although amlodipine did not change it significantly. Therefore, cilnidipine has a profound antihypertensive effect and may reduce the serum uric acid level and increase NO production in the kidney.